Murine IL-6 ELISA Kit
Product Specifications
- Catalogue N°
- 860.020.048 - 1 x 48 Discovery (pre-coated)
860.020.096 - 1 x 96 (pre-coated)
860.020.192 - 2 x 96 (pre-coated) - Assay Range
- 15.6 pg/ml - 500 pg/ml
- Sensitivity
- 10 pg/ml
- Target species
- Murine
- Specificity
- Recognizes both natural and recombinant murine IL-6
- Incubation
- 3h45
- Sample Type
- Serum, Cell culture supernatant
- Sample Size
- 100 µl
- Cross Reaction
- No cross reactivity with other murine cytokines
- Kit Content
- Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.
References
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- Castejón, M. L. et al., Nutrients. 2021 Feb; 13(2): 311. - Pubmed link
- García-Bernal, D. et al., J Cell Mol Med. 2020 Jul; 24(14): 8031–8044. - Pubmed link
- Santos, F. et al., Microb Cell Fact. 2020; 19: 42. - Pubmed link
- Nosaka, M. et al., Front Immunol. 2019; 10: 3150. - Pubmed link
- Thakur, R. et al., Sci Rep. 2019; 9: 18404. - Pubmed link
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BACKGROUND
Interleukin-6 (IL-6) is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis and may play a central role in host defense mechanisms.
This cytokine is involved in :
- the induction of B-cell differentiation,
- the induction of acute phase proteins in liver cells,
- growth promotion of myeloma/plasmacytoma/hybridoma cells,
- induction of IL-2 and IL-2 receptor expression,
- proliferation and differentiation of T cells,
- inhibition of cell growth of certain myeloid leukemic cell lines and induction of their differentiation to macrophages,
- enhancement of IL-3-induced multipotential colony cell formation in hematopoietic stem cells and induction of maturation of megakaryocytes as a thrombopoietic factor,
- induction of mesangial cell growth,
- induction of neural differentiation of PC cells
- induction of keratinocyte growth.
The abnormal production of IL-6 was first suggested to be related to polyclonal B-cell activation with autoantibody production in patients with cardiac myxoma. Since then, IL-6 has been suggested to be involved in the pathogenesis of a variety of diseases. Measurement of IL-6 levels in serum and other body fluids thus provides more detailed insights into various pathological situations.
Version 19 - 09.22
For research use only
For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.