Search for products

Anti-Human CD86 Azide Free

Product Specifications

Catalogue N°
853.830.000 - 200µg / 200µl
853.830.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises the B7.2, B70 antigen, a 80 kDa protein
Clone
B-S7
Application
ELISA
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
B70 transfected P815 cell line
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG2a Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Synonym
B7-2

BACKGROUND

CD86 (also known as B7-2) is a transmembrane glycoprotein member of the IgG superfamily. CD86 is expressed on antigen-presenting cells that provide co-stimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 (B7-1) to prime T cells and its co-stimulatory pathway plays an important role in the development of anti-tumour response.

Some studies have shown that CD86 expression by malignant cells is associated with a poor prognosis in both acute myeloid leukemia and multiple myeloma and a decrease of CD86 on PBM in melanoma results in an ineffective immune response.

A high level of soluble CD86 in plasma was described in several diseases: abdominal aortic aneurysm, leukaemia, systemic lupus erythematosus and acute asthma.

Version 6 - 06.19

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

853.830.000 200µg / 200µl
853.830.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human CD86 Azide Free 853.830.000 - 200µg / 200µl 853.830.005 - 500µg / 500µl )

Please contact us to discuss bulk orders