Rat VEGF-C ELISA kit

Product Specifications

Catalogue N°

670.110.096 - 1 x 96 (pre-coated)
670.110.192 - 2 x 96 (pre-coated)

Assay Range

47 pg/ml - 3000 pg/ml

Sensitivity

27pg/ml

Target species

Rat

Specificity

Recognizes both natural and recombinant rat VEGF-C

Incubation

3h30

Sample Type

Cell culture supernatant and serum tested, other body fluids suitable

Sample Size

50 µl

Kit Content

Diaclone ELISA Kits include pre-coated strip plates, biotinylated secondary antibody, standards, controls (where applicable), buffers, streptavidin-HRP, TMB, stop reagents and a detailed procedure.

BACKGROUND

Vascular endothelial growth factor-C (VEGF-C) is a member of the VEGF family of cytokines. It has been shown to exhibit angiogenic and lymphangiogenic actions. The VEGF family of growth factors and receptors is involved in the development and growth of the vascular endothelial system. Two of its family members, VEGF-C and VEGF-D, regulate the lymphatic endothelial cells via their receptor VEGFR3, thus acting as mitogens for these cells.

VEGF-C expression is associated with hematological malignancies. Like VEGF it acts as survival factor on leukemia. Together with the expression of their receptors, VEGF and VEGF-C result in the generation of autocrine loops that may support cancer cell survival and proliferation. Further VEGF-C expression has been shown in gastrointestinal tract malignancies where it correlates with lymphatic invasion, lymphnode metastasis and reduced survival of lymphatic endothelial cells.

 

Version 3 - 07.19

For research use only

Documents

• Rat VEGFc ELISA kit insert
• Safety Data Sheet ELISA Kits

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