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Anti-Human MICB FITC Conjugated

Product Specifications

Catalogue N°
855.521.010 - 100 tests / 1ml
Target species
Human
Specificity
Recognises both natural and recombinant human MICB
Clone
B-D54
Application
Flow Cytometry
Hybridoma
Myeloma X63/AG.8653 x Balb/c node cells
Immunisation
Recombinant human MICB
Quantity
100 Tests / 1ml (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline with 5% BSA and 0.1% sodium azide
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Working Dilution
Use 10 μl to label 106 cells or 100 μl of whole blood
Synonym
PERB11.2
Anti-Human MICB FITC Conjugated
A typical staining pattern with the B-D54 monoclonal antibody on Molt4 cell line

Sodium azide is a poisonous and hazardous substance, handle and dispose of properly


BACKGROUND

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within the MHC class I region of chromosome 6. Similar to MICA, MICB protein interacts with the natural killer cell receptor NKG2D and T cell receptor (TCR) and consequently activates the natural killer (NK) cells, gamma-delta (γδ) T cells and alpha-beta (αβ) CD8+ T cells, enhancing their cytolytic ability and cytokine production. Thus, the MICA/B–NKG2D pathway is an important mechanism by which the host immune system recognizes and kills transformed cells. This protein is stress and heat shock-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. It seems to have no role in antigen presentation.

In contrast to classical MHC class I molecules, MICA/B are expressed rarely on normal cells but frequently on tumor cells, including colon cancer, prostate cancer, hepatocellular carcinoma, and brain tumors. Also, soluble MICB serum levels were associated with various diseases such as multiple sclerosis, liver diseases, cancers and rheumatoid arthritis.

Version 4 - 06.19

For research use only

Documents

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Formats Available

855.521.010 100 tests / 1ml

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human MICB FITC Conjugated 855.521.010 - 100 tests / 1ml )

Please contact us to discuss bulk orders