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Anti-Human CD263 Azide Free

Product Specifications

Catalogue N°
854.890.000 - 200µg / 200µl
854.890.005 - 500µg / 500µl
Target species
Human
Specificity
Recognises DcR1 (CD263), a 75.90 kDa protein
Clone
B-D44
Application
Flow Cytometry
Functional assay
Hybridoma
Myeloma X63/AG.8653 x Balb/c spleen cells
Immunisation
Recombinant human TRAIL R3/Fc chimera
Quantity
200µg or 500µg (Discovery Size also available please enquire)
Isotype
Mouse IgG1 Kappa light chain
Format
Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
Storage
Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
Biological Activity
Inhibits TRAIL binding to TRAIL R3
Synonym
DcR1
TRAIL R3
Anti-Human CD263 Azide Free
A typical staining pattern with the B-D44 monoclonal antibody of granulocytes

BACKGROUND

Human Trail R3, also called DcR1, CD263, LIT, or TRID is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL with high affinity. In the Trail receptor family, Trail R3 (DcR1) but also Trail R4 (DcR2) antagonize TRAIL-induced apoptosis whereas Trail R1 (DR4) and Trail R2 (DR5) transduce an apoptosis signal. Trail R3 has extracellular TRAIL-binding cystein-rich domain but lacks intracellular signalling domain. Expression of Trail R3 has been shown to protect cells bearing Trail R1 and/or Trail R2 from Trail-induced apoptosis. Many tumor cell lines don’t express the decoy receptors and are therefore sensitive to TRAIL if they express Trail R1 and/or Trail R2.

Version 11 - 05.21

For research use only

Documents

For any order, the purchaser acknowledges having read and accepted the terms and conditions described on the Diaclone website.

Formats Available

854.890.000 200µg / 200µl
854.890.005 500µg / 500µl

Ordering options

Place an order
by phone: +33 (0)3 81 41 38 38
or by email: info [at] diaclone [dot] com ( Subject: Diaclone's order, Body: Anti-Human CD263 Azide Free 854.890.000 - 200µg / 200µl 854.890.005 - 500µg / 500µl )

Please contact us to discuss bulk orders