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Anti-Human CD130 Azide Free

Formats Available:

(852.080.000) 200µg / 200µl Azide free

 

Product Specifications

 

CATALOGUE N° :     852.080.000
CLONE :     B-P8
ISOTYPE :     Mouse IgG1
IMMUNISATION :     Natural soluble gp130
HYBRIDOMA :     Myeloma X63/AG.8653 x Balb/c spleen cells
SPECIFICITY :     Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein
WORKSHOP :     VI
QUANTITY :     200 µg / 200 µl (Discovery Size also available please enquire)
FORMAT :     Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free
STORAGE :     Stable at +2-8°C for 12 months
For longer storage, freeze aliquots
APPLICATION :     Suitable for flow cytometry
Inhibits CNTF activity and binding to gp130
Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation
Recognises the soluble antigen
REFERENCES :    
Aoki, Y. et al., Blood,2001; 98(10): 3042-9.
Chevalier, S. et al., J Biol Chem.,1996; 271(25): 14764-72.
Fischer, P. et al.,Biochem J.,2004;378(Pt 2): 449-60
Giese B. et al., J. Biol. Chem., 2003; 278(40) : 39205 - 39213
Giese, B. et al., J Cell Sci.,2005; 118(Pt 21): 5129-40.
Gu, Z. J. et al., Leukemia,2000; 14(1): 188-97.
Gu, Z. J. et al., J Immunol Methods,1996; 190(1): 21-7.
Haan, C. et al., Biochem J.,2000; 349(Pt 1): 261-6
Horsten, U. et al., J Biol Chem;,1997; 272(38): 23748-57.
Kurth, I. et al., J Immunol.,2000; 164(1): 273-82.
Lebeau, B. et al., FEBS Lett.,1997; 407(2): 141-7.
Müller-Newen G. et al., J. Biol. Chem., 2000; 275 (7) : 4578 - 4586
Olivier, C. et al., J Biol Chem.,2000; 275(8): 5648-56.
Rebouissou C. et al., Blood, 1998; 91(12) : 4727 - 4737
Simpson, R. J. et al., Protein Sci.,1997; 6(5): 929-55.
Timmermann, A. et al., Eur J Biochem.,2002; 269(11): 2716-26.
Wijdenes J. et al., Eur. J. Immunol., 1995; 25(12): 3474-81

graph
A typical staining pattern with the B-P8 monoclonal antibody of Eahy 926 cell line
Version 8 - 06.17                                                 For research use only