Biologically Active Antibodies

Investigate your cellular assay systems using the Diaclone range of Biologically Active Monoclonal Antibodies.

Diaclone offers a broad range of biologically active, Azide Free antibodies suitable for induction, activation, neutralisation and inhibition studies.

Specificity (Anti-Human)
Clone
Azide Free
Biological Activity
CD2
B-E2
Inhibits mixed lymphocyte culture
CD3
B-B11
Induces T lymphocyte stimulation and proliferation
CD4
B-A1
Inhibits mixed lymphocyte culture
CD10
B-E3
Cytotoxic In association with rabbit complement on CD10+ cells
CD20
B-H20
Cytotoxic in association with complement on CD20 cells
CD21
B-E5
Induces human B-cell proliferation and competes with EBV for CD21 binding.
CD25
B-B10
Inhibits mixed lymphocyte culture
CD25
B-F2
Inhibits mixed lymphocyte culture
CD28
B-T3
Inhibits mixed lymphocyte culture. Co-stimulates T-cell proliferation
CD34 Class I
B-G25
Triggers KG-1a cell aggregation
CD40
B-B20
Stimulates B-cell proliferation together with IL-4
CD44
B-F24
Triggers T-lymphocyte aggregation. Enhances Hyaluronan binding to CD44
CD54
B-H17
Inhibits PHA stimulated T-cell proliferation
CD86
B-T7
Inhibits mixed lymphocyte culture
CD95
B-G27
Triggers Fas induced apoptosis
CD95
B-D29
Inhibits FasL induced apoptosis
CD102
B-T1
Inhibits cell adhesion and T-cell activation
CD106
B-K9
Inhibits cell attachment to VCAM-1
CD117
B-K15
Inhibits the KIT ligand induced proliferation of TF1 cell line
CD126
B-R6
Inhibits IL-6 induced proliferation of XG-1 cells
CD126
B-F19
Inhibits IL-6 induced proliferation of XG-1 cell line. Inhibits IL-6 binding to its receptor
CD130
B-R3
Inhibits IL-6, IL-11, CNTF, LIF and OSM activities
CD130
B-K5
Inhibits CNTF activity. Inhibits OSM binding to gp130
CD130
B-P8
Inhibits CNTF activity and binding to gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation
CD130
B-P4
Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities
CD130
B-S12
Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation
CD178
B-R17
Inhibits soluble CD178 induced apoptosis
CD184
B-R24
Inhibits HIV-1 infection
CD202b
B-B48
Inhibits Tek-L / Tek binding
CD253
B-S23
Enhances TRAIL induced apoptosis
CD253
B-T24
Inhibits TRAIL induced apoptosis
CD261
B-N36
Neutralizes TRAIL induced apoptosis on HEL cell line
CD262
B-K29
Neutralizes TRAIL induced apoptosis of U937 cell line
CD262
B-D37
Agonist: induced apoptosis on Jurkat cells. Enhances TRAIL induced apoptosis of U937 cell line
CD263
B-D44
Inhibits TRAIL binding to TRAIL R3
CDw218a
B-E43
Inhibits human IFNγ secretion induced by IL-18 stimulated cells
CDw218b
B-B46
Inhibits human IFNγ secretion induced by IL-18 stimulated cells
HLA Class I
W6/32
Inhibits the interaction between T cells and MHC molecules
IFN-γ
B-B1
Inhibits IFNγ induced proliferation
IL-1b
B-A15
Inhibits IL-1β induced proliferation on D10S murine cell line
IL-2
B-G5
Inhibits IL-2 induced proliferation on CTL-L2 murine cell line
IL-4
B-S4
Inhibits IL-4 induced proliferation on TF1 cells
IL-6
B-E8
Inhibits IL-6 induced proliferation on B9 cells
IL-8
B-K8
Inhibits IL-8 induced chemotaxis of human neutrophils
IL-10
B-S10
Inhibits IL-10 induced proliferation on MC/9 cell line
IL-12p35+p70
B-T21
Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes
IL-12p40+p70
B-P24
Inhibits IL-12 induced proliferation on PHA and IL-2 activated lymphocytes
IL-13
B-B13
Inhibits IL-13 induced proliferation on TF1 cell line
IL-15
B-E29
Inhibits IL-15 induced proliferation on Kit 225 cell line
IL-17A
B-B51
Inhibits the bioactivity of IL-17A on keratinocytes cell line HaCaT (measurement of defensin-2 production)
IL-17F
B-F60
Neutralises the bioactivity of IL-17F on HT1080 cell line (measurement of IL-6 production)
IL-23
B-Z23
Inhibits the bioactivity of rhIL-23 on mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production)
NKp46
B-L46
The biological activity is measured by the ability of the coated antibody to induce degranulation of activated NK cells and to enhance IFNγ secretion by non-activated NK cells
NTR 1
B-N6
Inhibits neurotensin binding to its receptor
TNF-α
B-C7
Inhibits TNFα induced cytotoxicity on U937 cells
Visit www.diaclone.com for information about our full Monoclonal Antibody range for applications including Flow Cytometry, ImmunoHistochemistry, Immunoassay, Immunoflouresence and Western Blotting.